7.2.U3:  Nucleosomes help to regulate transcription in eukaryotes.

• Outline the effect of methylation of nucleosome tails on rates of gene expression.

• Outline the effect of acetylation of nucleosome tails on rates of gene expression.

7.2.S1:  Analysis of changes in the DNA methylation patterns.

• State the effect of DNA methylation on gene expression.

• Compare methylation patterns in twins using superimposed images of dyed chromosomes.

Gene expression “where are we?”

Intro to regulation of gene expression

Intro to gene expression handwritten

Regulation mechanisms table

Nucleosome regulation slides

Play doh model example

Paper nucleosome models 

Methyl and acetyl groups

A&B:  Genetics is so last century

A&B:  Altered States (twin studies)

A&B:  Hidden Switches in the mind 

A&B:  DNA's Histone Spools Hint at How Complex Cells Evolved 

7.1.U6:  Some regions of DNA do not code for proteins but have other important functions.

• Define “coding sequences” and “repetitive sequences” of DNA.

• Outline five functions of noncoding DNA sequences found in genomes, one of which must be the telomere. 

7.2.U1:  Gene expression is regulated by proteins that bind to specific base sequences in DNA.

• Define gene expression.

• State two reasons why gene expression must be regulated.

• Outline the environmental regulation of the breakdown of lactose in E. coli.

• Outline the role of enhancers, silencers and promoter-proximal elements in regulation of gene expression.

DNA switches notes

Enhancer gene model

Enhancers turn on genes

Transcriptional DNA textbook reading

Knowledgeable video: What do genes do?

Scitable:  some DNA regulates

Scitable:  gene expression

Lac Operon

Gene regulation in prokaryotes notes

Phet simulation

Lac operon model directions

Lac Operon model scoring

A&B:  genetic repressors (1970)

A&B:  the hidden genetic program

A&B:  the unseen genome

A&B:  Epigenome from radiolab

A&B:  Bird Flight Loss Tied to Switches

A&B:  how do genes switch on

A&B:  Inner Life of the Genome

A&B:  journey to the genetic interior

A&B:  regulating evolution

A&B:  Gene Enhancer Sequences Determine Craniofacial Development [Video]

A&B:  Bits of Mystery DNA, Far From ‘Junk,’ Play Crucial Role

A&B:  How the jerboa got its enormous feet

7.2.U2:  The environment of a cell and of an organism has an impact on gene expression.

• Describe the use of twin studies to measure the impact of the environment on gene expression.

• Outline two examples of environmental influence on gene expression.

7.2.NOS:  Looking for patterns, trends and discrepancies- there is mounting evidence that the environment can trigger heritable changes in epigenetic factors.

• Define epigenetic and epigenome.

• List types of epigenetic tags.

• Discuss the role of reprogramming and imprinting on epigenetic factors.

Environmental impact on DNA notes

TED:  early life written into DNA

TED:  Epigenetics and the influence of our genes

Scitable:  environmental influence on DNA

A&B:  DNA is not destiny

A&B:  how exercise changes our DNA

A&B:  from great grandma to you

A&B:  trait vs Fate

A&B:  Dutch famine scars

A&B:  The legacy of trauma (podcast)